How Compression Stockings Help Prevent Post-Thrombotic Syndrome (PTS)

Jeffrey H. Miller, M.D.
May 20
3 min read

A man pulling up compression stockings on his legs.

Post-thrombotic syndrome (PTS) remains one of the most common and debilitating long-term complications of deep vein thrombosis (DVT), affecting up to half of patients who experience a DVT. But what exactly is PTS?

In simple terms, PTS is a condition that can develop after a blood clot forms in a vein, typically in the leg. It can cause symptoms like pain, swelling, and skin changes, making everyday activities challenging and uncomfortable.

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New Information on Compression Stockings Effectiveness
What is a Meta-Analysis?
Key Takeaways from the Meta-Analysis
Reconsidering the SOX Trial
Conclusion
Take the Next Step Toward Healthier Legs

New Information on Compression Stockings Effectiveness

Despite evolving treatment strategies and occasional controversies in the literature, one thing is becoming increasingly clear: when it comes to compression therapy, consistency is key.

A recent meta-analysis study published in the journal Phlebology looks again at how graduated elastic compression stockings (ECS) can help prevent post-thrombotic syndrome (PTS). This study questions the results of an earlier study called the SOX trial, which said compression stockings didn't help.

The authors of the new study think the SOX trial's results were wrong because patients didn't wear the stockings regularly and started using them too late. The new study includes different types of research and shows that starting to wear stockings early and using them every day is important.

What is a Meta-Analysis?

For those unfamiliar with the term, a meta-analysis is a type of research that combines the results of multiple studies on a particular topic to draw a more comprehensive conclusion. Think of it as putting together pieces of a puzzle to see the bigger picture.

By analyzing data from various studies, researchers can identify patterns and trends that might not be visible in individual studies alone.

Key Takeaways from the Meta-Analysis

Wearing ECS (graduated elastic compression stockings) regularly can greatly lower the risk of developing post-thrombotic syndrome (PTS).

• For mild-to-moderate PTS, there was a 52% reduction in risk.

• For severe PTS, there was a 56% reduction in risk.

This means that if patients wear their compression stockings consistently, they have a much better chance of avoiding PTS.

Early Initiation Matters

Delaying compression stocking use after a DVT diagnosis decreases the chances of effective vein recanalization (the vein opening back up). It also decreases the chances of preservation of valve function.

Consistency Trumps Intention

Sporadic or occasional use of compression stockings (less than 4 days per week) offers little to no protective effect.

Individualized Treatment May be Sufficient

New evidence suggests that patients without PTS signs or symptoms at 3–6 months may be able to discontinue use of compression stockings safely.

Reconsidering the SOX Trial

Much of the skepticism about compression stocking effectiveness arose from the SOX trial.

However, this meta-analysis points to several flaws in the SOX methodology: delayed stocking distribution, lack of support in proper fitting, and low patient adherence (only about 56% of participants were still using ECS after 24 months).

These limitations underscore a critical point: using compression stockings only works if patients wear them properly and consistently.

Conclusion

This latest review adds meaningful clarity to the discussion on compression stocking effectiveness.

Despite past debate, the verdict is shifting. Compression stockings remain a vital tool in preventing PTS when used early and consistently. But one thing remains certain: Patient education, follow-up, and adherence are non-negotiable.

At Miller Vein, we're committed to staying ahead of the science and to continually educating our patients.

Reference

Nielsen, H., Hermann, M., & Fredskilde, L. (2024). Graduated elastic compression stockings in the prevention of post-thrombotic syndrome: A meta-analysis. Phlebology, 39(4)

Take the Next Step Toward Healthier Legs and a Better Life

If you have restlessness, heaviness, aching, swelling, throbbing, or itchiness in your legs—or you notice varicose veins or spider veins—it's time to see a vein specialist.

Schedule an appointment today to be certain about your vein health.

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